Anabolic steroids and their effects on fracture repair: literature review with clinical evidence synthesis
Keywords:Anabolic Steroids, Fracture Repair, Bibliographic Review
Background: The anabolic steroids applications in orthopedic surgery have historically been limited, with their use in the treatment of osteoporosis being a notable exception.
Aim: The national literature lacks sources on the therapeutic applications of anabolic steroids, especially in the case of fracture repair, therefore, the aim of this review was to provide a summary of the current status of this drugs applications for this purpose, with emphasis on in preclinical data and clinical studies.
Methodology: This is an exploratory research, based on the literature review method. The database used in was PUBMED, following this search strategy: “anabolic[title] AND steroids[title] AND fracture”. Papers published from 2012 to 2022 were included, excluding those that did not adequately discuss the proposed topic.
Results: Initially, 10 papers were extracted from the database that responded to the aforementioned strategy. After reading the titles and abstracts, no paper was rejected and the 10 articles were read in full, summarized, and discussed.
Conclusion: In general, the papers showed inconclusive results, tending to state that the use of anabolic steroids in fractures would not bring benefits, that is, there would be no improvement in bone healing markers in orthopedic trauma patients. Such results were repeated both in the isolated use of anabolic steroids and in their association with physical exercises, protein supplements and vitamin D.
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