Utilização da dieta cetogênica como estratégia para o manejo de pacientes com epilepsia refratária: uma revisão da literatura

Douglas Kovacs dos Santos; Paolo Ruggero Errante; Luis Carlos Barbosa Pontes-Junior; Alexandre Raphael Junior; Alexandre Raphael Junior; Patrícia Colombo-Souza; Renato Ribeiro Nogueira Ferraz; Francisco Sandro Menezes-Rodrigues

doi:10.37497/ijhmreview.v5i1.150

Use of the ketogenic diet as a strategy for the management of patients with refractory epilepsy: A literature review

Authors

Douglas Kovacs dos Santos Especialista em Farmacologia Clínica pelas Faculdades Oswaldo Cruz (FOC)
Paolo Ruggero Errante Pesquisador no Departamento de Farmacologia da Escola Paulista de Medicina - Universidade Federal de São Paulo (EPM-UNIFESP).
Luis Carlos Barbosa Pontes-Junior Graduando em Medicina na Universidade Santo Amaro (UNISA).
Alexandre Raphael Junior Professor da Universidade Santo Amaro, São Paulo.
Alexandre Raphael Junior Professor da Universidade Santo Amaro, São Paulo.
Patrícia Colombo-Souza Coordenadora de Pesquisa da Pesquisa da Universidade Santo Amaro (UNISA).
Renato Ribeiro Nogueira Ferraz Professor no Programa de Mestrado profissional em Administração – Gestão em Sistemas de Saúde (PMPA-GSS) – Universidade Nove de Julho (UNINOVE).
Francisco Sandro Menezes-Rodrigues Departamento de Farmacologia da Escola Paulista de Medicina - Universidade Federal de São Paulo (EPM-UNIFESP).

DOI:

https://doi.org/10.37497/ijhmreview.v5i1.150

Keywords:

Refractory epilepsy, Ketogenic diet, Quality of life.

Abstract

Introduction: Epilepsy is a disease that affects millions of people in all parts of the world. Epileptic seizures occur in patients in a partial or generalized way, depending on the degree of disease activity. Currently, there are many drugs available in the market, which have several mechanisms of action and can be used alone or concomitantly. However, in some patients, especially in children and adolescents, these drugs are ineffective and incapable of promoting the control of both the frequency and severity of epileptic seizures, which are called refractory epilepsy. Thus, the search for alternative treatments capable of controlling the frequency and intensity of refractory epileptic seizures is incessant and intense, and among the strategies currently used, the ketogenic diet (DC), which consists of a high lipid intake and low carbohydrate and protein intake and has provided an improvement in patients' quality of life, mainly in children and adolescents with refractory epilepsy. Objective: To review the literature on the benefits of CD, as an adjuvant and alternative treatment, in the treatment of refractory epilepsy, mainly in children and adolescents. Methodology: The study was carried out through a bibliographical and integrative review of the literature, through the compilation of scientific articles and books on the proposed theme. The information was searched in the Google academic database, Scielo and PubMed. The keywords used to search the scientific articles were: Epilepsy, Refractory Epilepsy, Ketogenic Diet. For the preparation of this study, publications were searched from 2008 to 2018, taking into account the relevance and relevance of the theme, whose title established the relationship with the study. Of the publications found, 22 were used. Conclusion: It is concluded that CHD presents itself as an important therapeutic option that is very safe, cheap and effective and, therefore, can be used in the management of patients with refractory epilepsy, mainly in children and adolescents.

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Published

2019-06-17

How to Cite

dos Santos, D. K., Errante, P. R., Pontes-Junior, L. C. B., Raphael Junior, A., Raphael Junior, A., Colombo-Souza, P., Ferraz, R. R. N., & Menezes-Rodrigues, F. S. (2019). Use of the ketogenic diet as a strategy for the management of patients with refractory epilepsy: A literature review. International Journal of Health Management Review, 5(1). https://doi.org/10.37497/ijhmreview.v5i1.150

Issue

Vol. 5 No. 1 (2019)

Section

Artigos

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